Control of Anticoagulant Therapy with a Chromogenic Substrate
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چکیده
منابع مشابه
Control of anticoagulant therapy with a chromogenic substrate.
Prothrombin is determined with the aid of a recently developed assay, based on the amidolysis of a chromogenic substrate. The assay proved to be reliable when it was compared with more conventional coagulation assays in the control of oral anticoagulant therapy, both in the therapeutic range and in a case of overdosage. As is the case in coagulation tests, heparin therapy remains a disturbing c...
متن کاملMaintenance control of oral anticoagulant therapy by a chromogenic substrate assay for factor X.
An amidolytic assay employing the chromogenic substrate S 2337 (Kabi Diagnostica) was used to assay factor X in 35 healthy controls and in 100 outpatients receiving oral anticoagulant therapy. This method correlated well with a coagulation assay of factor X in the control group (r = 0.88). When compared with two routine tests for the control of anticoagulant theray (Thrombotest and prothrombin ...
متن کاملControl of oral anticoagulant treatment by chromogenic prothrombin assay.
Doses of oral anticoagulants in 50 patients on long term treatment were easily and satisfactorily monitored over six months by an automated chromogenic assay of prothrombin (CPA). It is suggested that chromogenic assay of one or more of the vitamin K dependent coagulation factors would provide a readily standardised alternative to those conventional tests which depend on human brain derived rea...
متن کاملImproved control of long-term anticoagulant therapy.
mucosa or of the nails. Four women had taken iron tablets for long periods, but not for the six months previous to this investigation. During this time they had not observed any change in the ozaena. The Table contains the results of the haematological investigations. All patients had haemoglobin, haematocrit, and red cell count within normal limits. Serum iron was normal in eight patients, and...
متن کاملA chromogenic substrate method for detecting and titrating anti-factor VIII antibodies in the presence of lupus anticoagulant.
BACKGROUND AND OBJECTIVES The development of neutralizing anti-factor VIII antibodies (a-fVIII) is a major clinical complication. Lupus anticoagulant (LA) might affect detection of a-fVIII, since both inhibitors may act on the same coagulation pathway. Our aim was to accomplish unequivocal detection and titration of a-fVIII even in the presence of LA. DESIGN AND METHODS We evaluated a-fVIII a...
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ژورنال
عنوان ژورنال: Pathophysiology of Haemostasis and Thrombosis
سال: 1979
ISSN: 1424-8840,1424-8832
DOI: 10.1159/000214285